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US 12,215,090 B2Granted
Agents and methods for treating dysproliferative diseases
AssigneesMemorial Sloan Kettering Cancer Center, Tri-Institutional Therapeutics Discovery Institute, Inc.
InventorsYoshiyuki Fukase, Mark Duggan, Hans-Guido Wendel, Kamini Singh
Life of this patent
Estimating the term…
Abstract
Compounds are described with the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and n are defined as anywhere herein, which are useful for the treatment of cancer and other dysproliferative diseases.
Claims31
A compound represented by formula (I)
- wherein
- R1, R3, and R5 are each independently H, alkyl, —P(O)(OH)(OH), —CH2—P(O)(OH)(OH), —P(O)(OH)(O-alkyl), —CH2—P(O)(OH)(O-alkyl), —P(O)(O-alkyl)(O-alkyl), —CH2—P(O)(O-alkyl)(O-alkyl), or (CO)-alkyl, or a pharmaceutically acceptable salt of —P(O)(OH)(OH), —CH2—P(O)(OH)(OH), —P(O)(OH)(O-alkyl), or —CH2—P(O)(OH)(O-alkyl), and
- wherein at least one of R1, R3, and R5 is H, —P(O)(OH)(OH), —CH2—P(O)(OH)(OH), —P(O)(OH)(O-alkyl), —CH2—P(O)(OH)(O-alkyl), —P(O)(O-alkyl)(O-alkyl), —CH2—P(O)(O-alkyl)(O-alkyl), or a pharmaceutically acceptable salt of —P(O)(OH)(OH), —CH2—P(O)(OH)(OH), —P(O)(OH)(O-alkyl), or —CH2—P(O)(OH)(O-alkyl);
- R2 and R4 are each independently H, alkyl, halo, nitro, OH, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, NRaRb, (CO)-alkyl, (CO)OH, (CO)O-alkyl, SO2NRaRb, (CO)NRaRb, NH(CO)-alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein aryl and heteroaryl are optionally substituted with alkyl, halo, nitro, OH, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, and NRaRb;
- R6 is alkyl, halo, nitro, OH, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, NRaRb, (CO)-alkyl, (CO)OH, (CO)O-alkyl, SO2NRaRb, (CO)NRaRb, NH(CO)-alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein aryl and heteroaryl are optionally substituted with alkyl, halo, nitro, OH, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, and NRaRb;
- R7 is aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted with alkyl, halo, nitro, OH, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, and NRaRb;
- R8 and R9 are each independently H, OH, alkyl, halo, O-alkyl, SH, S-alkyl, CN, haloalkyl, O-haloalkyl, NRaRb, (CO)OH, (CO)O-alkyl, SO2NRaRb, (CO)NRaRb, or NH(CO)-alkyl;
- R10 is H, alkyl, (CO)-alkyl, or (CO)NRaRb;
- R11 and R12 are each independently H, OH, alkyloxy, cycloalkyloxy, heterocycloalkyloxy, cycloalkylalkyloxy, heterocycloalkylalkyloxy, arylalkyloxy, heteroarylalkyloxy, aryloxy, or heteroaryloxy;
- Ra and Rb are each H or alkyl, or Ra and Rb, together with the nitrogen atom they are attached, form a heterocycloalkyl group;
- and
- n is an integer from 0 to 4,
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.