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US 12,215,083 B2Granted
Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-n-benzylacetamide
AssigneeAtnx Spv, LLC
InventorMichael P. Smolinski
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Abstract
The present application provides solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide, and methods of preparing and using the same for the treatment of a cell proliferative disorder in which a tyrosine kinase plays a role.
Claims29
A method of preparing a Form B polymorph of Compound A:
- wherein
- the Form B polymorph is characterized by having X-ray powder diffraction peaks at approximately 6.4, 19.3, and 19.9°2θ using Cu Kα radiation, wherein approximately refers to ±0.3°2θ, wherein the method comprises:
- slurrying Compound A in chloroform.
A method of preparing the Form B polymorph of Compound A:
- wherein
- the Form B polymorph is characterized by having X-ray powder diffraction peaks at approximately 6.4, 19.3, and 19.9°2θ using Cu Kα radiation, wherein approximately refers to ±0.3°2θ, wherein the method comprises:
- adding an anti-solvent to a solution of Compound A in chloroform or acetonitrile, wherein the anti-solvent is isopropyl alcohol;
- adding an anti-solvent to a solution of Compound A in methanol, wherein the anti-solvent is isopropyl acetate;
- adding an anti-solvent to a solution of Compound A in acetone, wherein the anti-solvent is toluene;
- or
- allowing vapor of an anti-solvent to diffuse into a solution of Compound A in methanol or chloroform, wherein the anti-solvent is methyl tert-butyl ether.
4 more elements
A method of preparing the Form B polymorph of Compound A:
- wherein
- the Form B polymorph is characterized by having X-ray powder diffraction peaks at approximately 6.4, 19.3, and 19.9°2θ using Cu Kα radiation, wherein approximately refers to ±0.3°2θ, wherein the method comprises:
- slowly cooling a solution of Compound A in acetone, isopropyl acetate, 2-Me-THF, ethyl acetate, acetonitrile, a 1:3 mixture of chloroform and heptane, or a 1:3 mixture of dioxane and isopropyl acetate.
Dependencies are inferred from the claim text.