(e)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides as antitubercular agents
AssigneeKing Faisal University
InventorsKatharigatta N. Venugopala, Sandeep Chandrashekharappa, Melendran Pillay, Pran Kishore Deb, Rashmi Venugopala
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Abstract
Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are (E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides and their use as anti-tubercular agents.
Claims9
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is selected from the group consisting of hydrogen, halogen, cyano, and nitro.
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
- (E)-4-((Hydroxyimino)methyl)-1-(2-oxo-2-phenylethyl)pyridin-1-ium bromide (3a);
- (E)-1-(2-(4-Bromophenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridin-1-ium bromide (3b);
- (E)-1-(2-(4-Fluorophenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridin-1-ium bromide (3c);
- (E)-1-(2-(4-Cyanophenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridin-1-ium bromide (3d);
- (E)-4-((Hydroxyimino)methyl)-1-(2-(2-nitrophenyl)-2-oxoethyl)pyridin-1-ium bromide (3e);
- and a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof.
Dependencies are inferred from the claim text.