Treatment for loss of control disorders
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCasey Halpern, Robert C. Malenka, Hemmings Wu
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Abstract
The present invention provides, inter alia, methods, apparatus, and systems useful for ameliorating impulse control disorders known to be extremely disabling and common to many neurological and psychiatric conditions using closed-loop (responsive) neuro stimulation.
Claims9
A method of detecting an anticipatory biomarker in the form of a low frequency modulation in a nucleus accumbens of a subject in need thereof, wherein the subject in need is one diagnosed with, or suspected of having, a loss of control or impulse control disorder and wherein the subject in need has at least one electrode inserted into their nucleus accumbens, the method comprising:
- recording brain wave activity in a frequency range of from 0-38 hertz in the nucleus accumbens of the subject and in the absence of electrical stimulation administered to the brain;
- and
- detecting a change in power compared to a baseline in a delta band corresponding to a frequency of from 1-4 Hz,
- wherein detection of an increase in power in the delta band indicates detection of the anticipatory biomarker in the form of a low frequency modulation, wherein said low frequency modulation precedes the onset of a disorder symptom manifestation, wherein the method further comprises preventing the onset by administering, in response to detecting the anticipatory biomarker, an electrical stimulation to the nucleus accumbens of the subject.
A method of detecting an anticipatory biomarker in the form of a low frequency modulation in a nucleus accumbens of a subject in need thereof, wherein the subject in need is one diagnosed with, or suspected of having, a loss of control or impulse control disorder and wherein the subject in need has at least one electrode inserted into their nucleus accumbens, the method comprising:
- receiving brain wave activity in a frequency range of from 0-38 hertz that was recorded in the nucleus accumbens of the subject and in the absence of electrical stimulation administered to the brain;
- and
- detecting a change in power compared to a baseline in a delta band of the received brain wave activity corresponding to a frequency of from 1-4 Hz,
- wherein detection of an increase in power in the delta band indicates detection of the anticipatory biomarker in the form of a low frequency modulation, wherein said low frequency modulation precedes the onset of a disorder symptom manifestation, wherein the method further comprises preventing the onset by administering, in response to detecting the anticipatory biomarker, an electrical stimulation to the nucleus accumbens of the subject.
Dependencies are inferred from the claim text.