Multi-lumen drug delivery devices and methods
AssigneeTARIS Biomedical LLC
InventorHeejin Lee
Life of this patent
Estimating the term…
Abstract
Drug delivery devices are provided herein and include an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a water permeable wall structure having defining an elongated drug reservoir lumen extending between the first and second ends. One or more secondary lumens are structured (e.g., positioned, sized, shaped, and optionally filled) to be effective to retard or prevent in vivo diffusion of (i) water into the drug reservoir lumen and/or (ii) solubilized drug out of the drug reservoir lumen.
Claims31
A drug delivery device for controlled release of drug into the urinary bladder of a patient comprising:
- an elongated, elastic body extending between a closed first end and a closed second end, wherein the elastic body comprises a water permeable outer wall structure having a cylindrical shaped external surface extending between the first and second ends;
- an elongated hub structure located within, and coaxial with, the outer wall structure and extending between the first and second ends;
- two or more spoke structures extending between and connecting the outer wall structure and the hub structure, the spoke, outer wall, and hub structures defining at least one elongate drug reservoir lumen and at least one air lumen;
- and
- a drug payload disposed in the at least one drug reservoir lumen,
- wherein the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of the patient and a coiled retention shape which is suited to retain the device within the urinary bladder.
A drug delivery device comprising:
- an elongated, elastic body extending between a first end and a second end, wherein the elastic body comprises a water permeable first wall structure having an external surface and an internal surface defining an elongated drug reservoir lumen extending between the first and second ends;
- and
- a drug payload disposed in the drug reservoir lumen,
- wherein the elastic body comprises a second wall structure which in part defines one or more secondary lumens extending between the first and second ends and located between the second wall structure and the first wall structure, wherein the one or more secondary lumens are effective to retard or prevent in vivo diffusion of (i) water into the drug reservoir lumen and/or (ii) solubilized drug out of the drug reservoir lumen,
- wherein the first wall structure comprises an annulus in which the drug reservoir lumen is the central lumen of the annulus.
Dependencies are inferred from the claim text.