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US 12,214,106 B2Granted
Compositions comprising silk fibroin particles and uses thereof
AssigneeSofregen Medical, Inc.
InventorsAnh Hoang-Lindsay, Christopher P. Gulka, Jodie E. M. Giordano, Joseph E. Brown, Thomas L. Carroll
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Abstract
Various aspects described herein relate to compositions comprising silk fibroin particles and methods of using the same, as well as devices and methods of delivering such compositions. The compositions described herein are suitable for injection into a site of defect in a soft tissue to provide bulking and/or augmentation effect to the soft tissue.
Claims8
An injectable composition comprising:
- crosslinked hyaluronic acid;
- and
- silk fibroin particles having an average particle size of about 50 um to about 1000 um, wherein:
- the crosslinked hyaluronic acid has a crosslink density of about 4 mol % to about 30 mol %,
- the crosslinked hyaluronic acid has a concentration in the injectable composition of greater than or equal to about 1% (w/v) and less than or equal to about 10% (w/v),
- the silk fibroin particles are hydrated, and
- the silk fibroin particles have an average hydrated density of about 0.4 g/mL particles to about 1 g/mL particles.
4 more elements
Dependencies are inferred from the claim text.