Transdermal therapeutic system for the transdermal administration of guanfacine comprising at least one additive
AssigneesLTS Lohmann Therapie-Systeme AG, DDP Specialty Electronic Materials US 9, LLC
InventorsMarco Emgenbroich, Eva-Marie Prinz, Elke Klein, Heike Kluth, Xavier Thomas, Linda Sue Nartker
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Abstract
The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising: A) a backing layer; and B) a guanfacine-containing layer; wherein the transdermal therapeutic system comprises at least one polymer and at least additive.
Claims10
A transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising:
- A) a backing layer;
- and
- B) a guanfacine-containing layer;
- wherein the transdermal therapeutic system comprises at least one polymer and a combination of a dispersing agent, a permeation enhancer, and a solubilizer;
- wherein the dispersing agent is a polyethylene glycol C8-C20-alkyl ether having from 2 to 10 EO units, the permeation enhancer is oleyl alcohol, and the solubilizer is a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer.
Dependencies are inferred from the claim text.