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US 12,214,071 B2Granted
Topical composition containing antioxidants
OwnerAldo Laghi, Nathaniel Vintinventors
Life of this patent
Estimating the term…
Abstract
Compositions for topical application that effectively deliver antioxidants across the epidermis, dermis, or a combination thereof into cells and/or the bloodstream while concurrently maintaining chemical activity of the antioxidants. In certain aspects, these formulations include emulsions and balms each having a lipophilic carrier and a lipophilic antioxidant solubilized by the lipophilic carrier. Also disclosed herein are methods for making these compositions for topical application.
Claims3
A topical composition comprising:
- 30-75 percent by weight water;
- 3-6 percent by weight surfactant;
- 1-50 percent by weight lipophilic carrier having a molecular weight between 150 and 600;
- 0.25-4 percent by weight lipophilic antioxidant having a formula:
- wherein:
- R1 represents a C1 to C9 linear or branched alkyl group or styrene;
- R2 is optional and represents a C1 to C6 linear or branched alkyl group or styrene;
- Y1 represents a C1 to C6 linear or branched alkyl group, styrene, —SR5, or —(CH2)nCOOR6;
- n is from 1 to 10;
- R5 represents isoprene, a methyl group, an ethyl group, a propyl, a butyl, a pentyl group, a hexyl group, an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a tert-pentyl group, a neo-pentyl group, an isopentyl group, an isohexyl group, a neohexyl group, styrene, or
- wherein R11, R12, and R13 independently represent OH, a methyl group, ethyl group, a propyl group, a butyl group, an isopropyl group, a tert-butyl group, an isoprene, or a tert-pentyl group;
- R6 represents an alkyl group having C10 to C30;
- and
- wherein the formula includes pharmaceutically acceptable salts thereof;
- 1-10 percent by weight skin penetration enhancer;
- 9-11 percent by weight paraffinic oil;
- and
- 0.5-5 percent by weight of a preservative mixture comprising propylene glycol, diazolidinyl urea, methylparaben, and propylparaben and tetrasodium ethylenediaminetetraacetic acid;
- wherein once the topical composition is compounded, the topical composition is a cream emulsion.
16 more elements
A topical composition comprising:
- 30-75 percent by weight water;
- 3-6 percent by weight surfactant;
- 1-50 percent by weight lipophilic carrier having a molecular weight between 150 and 600;
- 0.25-4 percent by weight lipophilic antioxidant having a formula:
- wherein:
- R3 and R4 independently represent a C1 to C6 branched alkyl;
- Y2 represents a C1 to C6 linear or branched alkyl group, —R5, or —(CH2)nCOOR6;
- R5 represents isoprene, a methyl group, an ethyl group, a propyl, a butyl, a pentyl group, a hexyl group, an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a tert-pentyl group, a neo-pentyl group, an isopentyl group, an isohexyl group, a neohexyl group, styrene, or
- wherein R11, R12, and R13 independently represent OH, a methyl group, ethyl group, a propyl group, a butyl group, an isopropyl group, a tert-butyl group, an isoprene, or a tert-pentyl group, and
- R6 represents an alkyl group having C10 to C30;
- n is from 1 to 10;
- and
- wherein the formula includes pharmaceutically acceptable salts thereof;
- 1-10 percent by weight skin penetration enhancer;
- 9-11 percent by weight paraffinic oil;
- and
- 0.5-5 percent by weight of a preservative mixture comprising propylene glycol, diazolidinyl urea, methylparaben, and propylparaben and tetrasodium ethylenediaminetetraacetic acid;
- wherein once the topical composition is compounded, the topical composition is a cream emulsion.
15 more elements
A topical composition comprising:
- 30-75 percent by weight water;
- 3-6 percent by weight surfactant;
- 1-50 percent by weight lipophilic carrier having a molecular weight between 150 and 600;
- 0.25-4 percent by weight lipophilic antioxidant having a formula:
- wherein:
- R3 and R4 independently represent a C1 to C6 branched alkyl;
- Y3 represents a linear or branched alkyl group having C10 to C30;
- and
- wherein the formula includes pharmaceutically acceptable salts thereof;
- 1-10 percent by weight skin penetration enhancer;
- 9-11 percent by weight paraffinic oil;
- and
- 0.5-5 percent by weight of a preservative mixture comprising propylene glycol, diazolidinyl urea, methylparaben, and propylparaben and tetrasodium ethylenediaminetetraacetic acid;
- wherein once the topical composition is compounded, the topical composition is a cream emulsion.
11 more elements
Dependencies are inferred from the claim text.