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US 12,214,056 B2Granted
Therapeutic applications of CPF1-based genome editing
AssigneeDuke University
InventorsCharles A. Gersbach, Sarina Madhavan, Christopher Nelson
Life of this patent
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Abstract
Disclosed herein are therapeutic applications of CRISPR/Cpf1-based genome editing.
Claims12
A DNA targeting composition comprising a first Cpf1 gRNA and a second Cpf1 gRNA selected from the group consisting of:
- (i) a first Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 54 and a second Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 62;
- (ii) a first Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 55 and a second Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 63;
- and
- (iii) a first Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 56 and a second Cpf1 gRNA comprising a polynucleotide encoded by the sequence of SEQ ID NO:
- 61.
7 more elements
Dependencies are inferred from the claim text.