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US 12,214,048 B2Granted
Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a TLR peptide agonist for use in medicine
AssigneeAmal Therapeutics SA
InventorsMadiha Derouazi, Elodie Belnoue
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Abstract
The present invention provides a combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, at least one antigen or antigenic epitope, and a TLR peptide agonist for use in medicine, in particular in the prevention and/or treatment of cancer. Moreover, the present invention also provides compositions, such as a pharmaceutical compositions and vaccines, which are useful in medicine, for example in the prevention and/or treatment of cancer.
Claims32
A combination comprising:
- (i) an immune checkpoint modulator, and
- (ii) a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist, and
- wherein components a)-c) are covalently linked.
4 more elements
A kit comprising:
- (i) an immune checkpoint modulator;
- and
- (ii) a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist;
- and
- wherein components a)-c) are covalently linked;
- and
- (iii) a package insert or label having directions to treat cancer.
8 more elements
A pharmaceutical composition comprising:
- (i) an immune checkpoint modulator;
- and
- (ii) a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist;
- and
- wherein components a)-c) are covalently linked.
6 more elements
A combination comprising:
- (i) an immune checkpoint modulator;
- and
- (ii) a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist;
- wherein components a)-c) are covalently linked, and
- wherein the complex is a recombinant polypeptide or a recombinant protein.
6 more elements
Dependencies are inferred from the claim text.