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US 12,214,034 B2Granted
Vaccines against HPV and HPV-related diseases
AssigneeBaylor Research Institute
InventorsSangkon Oh, Sandra Zurawski, Gerard Zurawski
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AssigneeBaylor Research Institute
InventorsSangkon Oh, Sandra Zurawski, Gerard Zurawski
Estimating the term…
Embodiments relate to novel vaccines against human papillomavirus (HPV) and HPV-related diseases, including multiple types of cancers. The HPV vaccines are composed of anti-human dendritic cell (DC) surface receptor antibodies, including CD40, and E6/7 proteins of HPV16 and 18. The technology described is not limited to making vaccines against HPV16- and HPV18-related diseases and can be applied to making vaccines carrying E6/7 from any type of HPV. The HPV vaccines described can target DCs, major and professional antigen presenting cells (APCs), and can induce and activate potent HPV E6/7-specific and strong CD4+ and CD8+ T cell responses. The HPV vaccines can be used for the prevention of HPV infection and HPV-related diseases as well as for the treatment of HPV-related diseases, including cancers.
One or more nucleic acids encoding a fusion protein comprising an anti-CD40antibody or fragment thereof, comprising at least three complementarity determining regions (CDRs) from each of a heavy and light chain of an anti-CD40 antibody, at least one peptide linker and at least one human papillomavirus (HPV) E6 antigen and at least one HPV E7 antigen, wherein the E6 and E7 antigens comprise an antigen with at least 90% sequence identity to SEQ ID NO:
One or more nucleic acids encoding a fusion protein comprising an anti-CD40antibody or fragment thereof, comprising at least three complementarity determining regions (CDRs) from each of a heavy and light chain of an anti-CD40 antibody, at least one peptide linker and at least one human papillomavirus (HPV) E6 antigen and at least one HPV E7 antigen, wherein the E6 and E7 antigens comprise an antigen with at least 90% sequence identity to SEQ ID NO:
Dependencies are inferred from the claim text.