Immunogenic formulation that induces protection against shiga toxin-producing Escherichia coli (STEC)
AssigneeUniversidad De Chile
InventorsRoberto Mauricio Vidal Alvarez, Felipe Antonio Del Canto Fuentes, David Arturo Montero Forero, Juan Carlos Salazar Garrido
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Abstract
Disclosed is an immunogenic formulation that induces protection against Shiga Toxin-Producing Escherichia coli (STEC), the formulation comprising: one or more chimeric proteins derived wholly or in part from OmpT and Hes proteins of STEC; and at least one physiologically or pharmaceutically acceptable excipient, carrier and/or diluent.
Claims9
An immunogenic formulation that induces protection against shiga Toxin-Producing Escherichia coli (STEC), the formulation comprising:
- (i) a chimeric protein derived from OmpT and Hes proteins of STEC, having the amino acid sequence as set forth in SEQ ID NO:
- 1;
- (ii) a second chimeric protein derived from α-Cah protein of STEC, having the amino acid sequence as set forth in SEQ ID NO:
- 2;
- and
- (iii) at least one physiologically or pharmaceutically acceptable excipient, carrier and/or diluent.
A chimeric protein derived from OmpT and Hes proteins of shiga toxin-producing E. coli (STEC) comprising immunogenic epitopes having the amino acid sequence as set forth in SEQ ID NO:
- 1.
A chimeric protein derived from α-Cah protein of shiga toxin-producing E. coli (STEC) comprising the amino acid sequence as set forth in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.