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US 12,214,026 B2Granted
Vaccine for falciparum malaria
AssigneesRhode Island Hospital, Seattle Children's Hospital
InventorsJonathan Kurtis, Christian Parcher Nixon, Dipak Kumar Raj, Jennifer Frances Friedman, Michal Fried, Patrick Emmet Duffy
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Abstract
The invention provides compositions and methods for preventing or reducing the severity of malaria.
Claims8
A method for reducing the severity of malaria or immunizing against malaria in a subject, comprising the step of administering a composition to the subject;
- wherein the composition comprises a polypeptide selected from the group consisting of:
- CDPK5 (SEQ ID NO:
- 47), SERA5 (SEQ ID NOS:
- 70, 72), PfSUB1 (SEQ ID NO:
- 74), and PfPKG (SEQ ID NO:
- 76) or a combination of polypeptides thereof;
- wherein the administration of the composition including the polypeptide or combination of polypeptides elicits an immune response to the polypeptide or combination of polypeptides;
- wherein the immune response inhibits schizont egress from red blood cells;
- thereby reducing the severity of malaria or immunizing against malaria in the subject.
6 more elements
Dependencies are inferred from the claim text.