Study on lactoferrin regulation of bone formation by means of vitamin D receptor
AssigneeChina Agricultural University
InventorsHuiyuan Guo, Yixuan Li, Hao Zhang, Liang Zhao
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Abstract
A use of lactoferrin in the preparation of a food or drug, the food or drug being used for activating a VDR signaling pathway, which is used for the treatment of bone disease, bone disease comprising: osteoporosis, bone damage, loss of bone calcium, incomplete bone development and bone abnormalities. The present invention further comprises screening for drugs that are used to promote osteoblast proliferation and differentiation by using an active state of the VDR signaling pathway.
Claims12
A method of treating Vitamin D (VD)-deficient osteoporosis, comprising administering to a patient in need thereof lactoferrin at a dose of 100 mg/kg Body Weight (BW),
- wherein Vitamin D Receptor (VDR) gene and protein levels increase in the patient.
A method of treating Vitamin D (VD)-deficient osteoporosis, comprising administering to a patient in need thereof lactoferrin at a dose of 100 mg/kg Body Weight (BW) and 1.25(OH)2D3,
- wherein the concentration of 1.25(OH)2D3 is 1 or 10 nM, and
- wherein Vitamin D Receptor (VDR) gene and protein levels increase in the patient.
Dependencies are inferred from the claim text.