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AssigneesThe Trustees of the University of Pennsylvania, The Regents of the University of California
InventorsGeorge Cotsarelis, Christian F. Guerrero-Juarez, Maksim Plikus
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This invention describes methods for treating wound healing pathologies, inhibiting or reversing fibrotic skin disorders, including but not limited to keloids, atrophic and hypertrophic scars, and reversing skin aging via generating new dermal adipocytes (DAs). Methods described herein comprise (a) grafting of human hair follicles or (b) direct delivery of conditioned media from in vitro cultured hair follicles, or (c) delivery of purified individual factors secreted by hair follicles, or (d) delivery of small molecule agonists that mimic hair derived signaling activities, or (e) delivery of small molecule antagonists that inhibit anti-adipogenic programs, or (f) delivery of small molecule agonists of pro-adipogenic programs to convert endogenous wound or scar skin fibroblasts into new DAs.
A method for treating wound healing pathologies or for inhibiting or suppressing a fibrotic skin disorder in a subject having a wound healing pathology or fibrotic skin disorder, the method comprising the step of administering to the subject a composition consisting of therapeutically effective amount of a wild-type bone morphogenetic protein 2 (BMP2) polypeptide, or a wild-type bone morphogenetic protein 4 (BMP4) polypeptide, or a combination thereof.
Dependencies are inferred from the claim text.