Methods of treatment of arthritis and/or psoriasis with pharmaceutical formulations of etanercept
AssigneeAmgen Inc.
InventorsMonica Goss, Nicole Ball
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Abstract
The invention relates to the formulation of pharmaceutical compositions of etanercept. The invention also relates to methods of removing buffer and of formulating pharmaceutical compositions of etanercept.
Claims48
A method of treating a patient having rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or psoriasis, comprising administering to said patient a pharmaceutical composition comprising between 75 mM and 150 mM NaCl, between 5 mM and 100 mM arginine, between 0.5% and 2% (w/v) sucrose, and between 40 mg/mL and 100 mg/mL etanercept, wherein the pharmaceutical composition comprises less than 2.0 mM total additional buffering agent, and the pH of the pharmaceutical composition is between 6.1 and 6.5.
Dependencies are inferred from the claim text.