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US 12,214,010 B2Granted
Desmopressin oral compositions
AssigneeTulex Pharmaceuticals Inc.
InventorsYu-Hsing Tu, Kalyan Kathala, Romona Bhattacharya, Yingjun Fan, Ashok Perumal
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Abstract
Provided herein are desmopressin oral liquid formulations. Also provided herein are methods of making and using desmopressin oral liquid compositions for the treatment of certain diseases including diabetes insipidus, enuresis, hemophilia A, von willebrand disease, high blood urea levels and others.
Claims22
A liquid pharmaceutical composition comprising
- a) desmopressin acetate, wherein desmopressin acetate is present in an amount of from about 0.01 mg/mL to about 0.1 mg/mL;
- b) a two-component, dual-functional, preservative-buffer system that comprises sodium benzoate and
- benzoic acid, wherein the two-component, dual-functional, preservative-buffer system provides a pH of the liquid pharmaceutical composition that is about 5.0;
- and
- c) water;
- wherein the liquid pharmaceutical composition is an oral solution.
3 more elements
Dependencies are inferred from the claim text.