Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
AssigneeDirect Biologics, LLC
InventorsKenneth Allen Pettine, Timothy Alexander Moseley
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Abstract
Disclosed are compositions comprising a MSC secretome preparation and cannabinoids and methods of the use of said compositions for the treatment of inflammatory conditions.
Claims8
A composition comprising:
- i) a mesenchymal stem cell (MSC) secretome preparation comprising MSC growth factors, MSC extracellular vesicles, MSC exosomes, and/or MSC extracts;
- and
- ii) a cannabinoid;
- wherein the MSC growth factors, MSC extracellular vesicles, MSC exosomes, and/or MSC extracts are obtained from human bone-marrow MSCs cultured under conditions comprising about 0.1% to about 5% oxygen and an acidic pH of 6.2 to 6.9.
A method of treating an inflammatory condition, an autoimmune disease, an autoinflammatory disease, or metabolic disorder, in a subject, the method comprising culturing bone-marrow mesenchymal stem cells (MSCs) under conditions comprising about 0.1% to about 5% oxygen and an acidic pH of 6.2 to 6.9 to generate a mesenchymal stem cell (MSC) secretome preparation, and administering to the subject a therapeutically effective amount of the MSC secretome preparation and a cannabinoid.
A method of treating inflammation in a subject, the method comprising culturing bone-marrow mesenchymal stem cells (MSCs) under conditions comprising about 0.1% to about 5% oxygen and an acidic pH of 6.2 to 6.9 to generate a mesenchymal stem cell (MSC) secretome preparation and administering to the subject a therapeutically effective amount of the MSC secretome preparation and a cannabinoid.
Dependencies are inferred from the claim text.