Madrasin-derivative compounds, composition and uses thereof for treating cancer

A kit comprising a compound and at least one anticancer agent in distinct containers, wherein the compound is selected from the group consisting of:

• 5,6-Dimethyl-2-((4-methyl-7-(2-morpholinoethoxy)quinazolin-2-yl)amino)pyrimidin-4(3H)-one
• Sodium 2-((4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)amino)-4-methylquinazolin-7-yl phosphate
• and
• wherein:
• R1 and R2 are independently selected from H, CH3 (Methyl), Cl (Chlorine), and a thiosugar, and
• R3 is
• wherein:
• R4 is absent, H, CH3 (Methyl), C2H5 (Ethyl) or n-Propyl,
• Z is CH2 or C═O,
• n is 1, 2 or 3, and
• X is O, N or CH.

A method for treating a carcinoma, sarcoma or blastoma in a subject by ameliorating the disease state of the subject, wherein the method comprises administering a subject in need thereof with a compound selected from:

• 5,6-Dimethyl-2-((4-methyl-7-(2-morpholinoethoxy)quinazolin-2-yl)amino)pyrimidin-4(3H)-one
• Sodium 2-((4,5-dimethyl-6-oxo-1,6-dihydropyrimidin-2-yl)amino)-4-methylquinazolin-7-yl phosphate
• and
• wherein:
• R1 and R2 are independently selected from H, CH3 (Methyl), Cl (Chlorine), and a thiosugar, and
• R3 is
• wherein:
• R4 is absent, H, CH3 (Methyl), C2H5 (Ethyl) or n-Propyl,
• Z is CH2 or C═O,
• n is 1, 2 or 3, and
• X is O, N or CH.