Methods and compositions for treating melanoma
AssigneeThe Regents of the University of California
InventorsThomas G. Graeber, Jennifer Tsoi, Antoni Ribas, Lidia Robert, Nicolaos Palaskas
Life of this patent
Estimating the term…
Abstract
The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.
Claims12
A method for treating or preventing BRAF inhibitor resistance in a subject having dedifferentiated melanoma, the method comprising administering a GPX4 inhibitor and a BRAF inhibitor in parallel.
A method for treating a subject having dedifferentiated melanoma, the method comprising administering a GPX4 inhibitor to the subject, wherein the subject is being treated in parallel with a BRAF inhibitor.
Dependencies are inferred from the claim text.