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US 12,213,973 B2Granted
Bacterial nitric oxide synthase inhibitors
AssigneeNorthwestern University
InventorsRichard Bruce Silverman, Pathum Manjula Weerawarna
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Abstract
Disclosed are substituted aminoquinoline and aminopyridine compounds and their use as bacterial nitric oxide synthase (bNOS) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject having or at risk for developing a disease or disorder that is associated with bNOS activity.
Claims20
A compound of a Formula I(a) or I(b), or a salt thereof:
- wherein if the compound has the formula I(a), then:
- (i) X is CH2 or O;
- L is aza-substituted alkylene of a formula —(CH2)mNH(CH2)n—, m and n being an integer independently selected from 0 to 4;
- and
- R is an optionally substituted pyridyl or an amino;
- or
- (ii) X is CH2 or O;
- L is alkylene;
- and
- R is an optionally substituted pyridyl;
- and
- wherein if the compound has the formula I(b), then:
- X is O;
- L is aza-substituted alkylene;
- and
- R is pyridyl substituted with amino.
13 more elements
Dependencies are inferred from the claim text.