Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
AssigneeGreat Novel Therapeutics Biotech & Medicals Corporation
InventorsJia-Shiong Chen, Mu-Hsuan Yang, Yi-Hong Wu, Sz-Hao Chu, Cheng-Han Chou, Ye-Su Chao, Chia-Nan Chen
Life of this patent
Estimating the term…
Abstract
The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.
Claims21
A method for epigenetic immunomodulation of tumor microenvironment (TME) and/or treatment of cancer in a subject in need thereof, the method comprising administrating an effective amount of a compound of formula (I) to the subject:
- wherein W and Y are each independently selected from CH and N;
- R1 is each independently selected from hydrogen, halogen, C1-C3 alkyl and halogenated C1-C3 alkyl, and can be mono-, di-, tri- or tetra-substitution;
- C1 and C2 are C atoms linked by a double bond;
- Ar is selected from the group consisting of the following:
- wherein Ar is linked to C2 via the solid line;
- R2 has the same meaning as described for R1;
- and
- R3 is hydrogen or C1-C3 alkyl;
- or a pharmaceutically acceptable salt, hydrate, stereoisomer or solvate thereof.
A method for treating or preventing the disease associated with class I HDAC in a subject in need thereof comprising administrating an effective amount of a compound of formula (I) to the subject:
- wherein W and Y are each independently selected from CH and N;
- R1 is each independently selected from hydrogen, halogen, C1-C3 alkyl and halogenated C1-C3 alkyl, and can be mono-, di-, tri- or tetra-substitution;
- C1 and C2 are C atoms linked by a double bond;
- Ar is selected from the group consisting of the following:
- wherein Ar is linked to C2 via the solid line;
- R2 has the same meaning as described for R1;
- and
- R3 is hydrogen or C1-C3 alkyl;
- or a pharmaceutically acceptable salt, hydrate, stereoisomer or solvate thereof.
Dependencies are inferred from the claim text.