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US 12,213,968 B2Granted
Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoropheyl)-3-phenylurea
AssigneeDeciphera Pharmaceuticals, LLC
InventorsMichael D. Kaufman, Scott Bone, Corey Bloom, Fred Jordan
Life of this patent
Estimating the term…
Abstract
Provided herein are low impurity compositions comprising a compound represented by Formula (I): which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
Claims18
A pharmaceutical composition comprising:
- a solid dispersion comprising:
- a compound represented by Formula (I) or pharmaceutically acceptable salt thereof,
- and hydroxypropylmethyl cellulose acetate succinate;
- and
- wherein a compound represented by Formula (II):
- is present in an amount equal to or less than about 10% by weight based on the weight of the compound of Formula (I) present in the composition.
3 more elements
A pharmaceutical composition comprising:
- a solid dispersion comprising:
- a compound represented by Formula (I) or pharmaceutically acceptable salt thereof,
- and hydroxypropylmethyl cellulose acetate succinate;
- and
- wherein a compound represented by Formula (III):
- is present in an amount equal to or less than about 10% by weight based on the weight of the compound of Formula (I) present in the composition.
3 more elements
A pharmaceutical composition comprising:
- a solid dispersion comprising:
- a compound represented by Formula (I) or pharmaceutically acceptable salt thereof,
- and hydroxypropylmethyl cellulose acetate succinate;
- and
- aniline in an amount equal to or less than about 10% by weight based on the weight of the compound of Formula (I) present in the composition.
2 more elements
A pharmaceutical composition comprising:
- a solid dispersion comprising:
- a compound represented by Formula (I) or pharmaceutically acceptable salt thereof,
- and hydroxypropylmethyl cellulose acetate succinate;
- and
- diphenyl urea in an amount equal to or less than about 3% by weight based on the weight of the compound of Formula (I) present in the composition.
2 more elements
Dependencies are inferred from the claim text.