US 12,213,963 B2 · Topical formulation of disease-modifying antirheumatic drug (DMARDs) for the treatment of rheumatoid arthritis, melanoma, squamous cell carcinoma, atopic dermatitis, and psoriasis

Abstract

The present invention relates to a composition of disease-modifying antirheumatic drugs (DMARDs) for treatment of auto-immune diseases. More particularly, the invention relates to the microemulsion based emulgel composition of DMARD-leflunomide or its derivatives for treatment of auto-immune diseases such as rheumatoid arthritis, atopic dermatitis, psoriasis and skin cancer such as melanoma, squamous cell carcinoma. The invention also discloses a method for preparation of microemulsion based emulgel composition with improved physicochemical, pharmacokinetic properties of leflunomide to be used in pharmaceutical compositions. This invention discloses the delivery of leflunomide across human skin for the treatment of autoimmune and oncological conditions. The unique delivery of leflunomide in the form of microemulsion based emulgel composition is disclosed.

Claims4

Dependent claims

A topical microemulsion-based emulgel composition comprising:

a. 0.5-1.0 (% w/v) leflunomide;
b. 5 (% w/v) propylene glycol monocaprylate;
c. 3.75 (% w/v) polysorbate 20;
d. 3.75 (% w/v) polyoxyl 40 hydrogenated castor oil;
e. 7.5 (% w/v) polyethylene glycol 400;
f. 2.5 (% w/v) carbomer;
and
g. q.s. water.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/047,707Filed 19 Oct 2022

Published

US 2024/0131008 A125 Apr 2024

Granted

4 Feb 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 31/42
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: oxazoles
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/1075
Emulsions ; Emulsion preconcentrates; Micelles: microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of…
A61K 31/277
Nitriles; Isonitriles: having a ring, e.g. verapamil

Topical formulation of disease-modifying antirheumatic drug (DMARDs) for the treatment of rheumatoid arthritis, melanoma, squamous cell carcinoma, atopic dermatitis, and psoriasis

Life of this patent

Topical formulation of disease-modifying antirheumatic drug (DMARDs) for the treatment of rheumatoid arthritis, melanoma, squamous cell carcinoma, atopic dermatitis, and psoriasis

Life of this patent

Abstract

Claims4