Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
AssigneeResearch Cancer Institute of America
InventorMohammed Amin Nezami
Life of this patent
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Abstract
Provided herein are compositions, methods, systems and/or kits for preventing and/or treating neoplasms using at least one modulator selected from quercetin, sodium phenyl butyrate and epigallocatechin-3-gallate in combination with one or more anti-cancer agents. The compositions, methods, systems and/or kits are used to prevent and/or treat neoplasms that are resistant to the one or more anti-cancer agents when administered alone. Also provided are nanoformulations based on nanoparticles with one or more anti-cancer agents and/or one or more modulators for preventing and/or treating neoplasms.
Claims42
A pharmaceutical composition, comprising:
- synergistic amounts of:
- Afatinib;
- and
- a first anti-cancer response modulator,
- wherein the first anti-cancer response modulator is quercetin, and
- wherein the synergistic amounts of Afatinib and quercetin are effective for treatment of a neoplasm.
A method of treatment of a neoplasm, the method comprising:
- administering in a pharmaceutical composition, to a patient in need thereof,
- synergistically effective amounts of:
- Afatinib;
- and
- a first anti-cancer response modulator, wherein the first anti-cancer response modulator is quercetin.
Dependencies are inferred from the claim text.