Method of treating fatty acid oxidation disorders using omega3/omega6 unsaturated or branched chain fatty acids
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorAl-Walid A. Mohsen
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Abstract
A method of treating medium chain acyl-CoA dehydrogenase deficiency, very long chain acyl-CoA dehydrogenase deficiency, long chain hydroxyacyl-CoA dehydrogenase deficiency, trifunctional protein deficiency, or CPT II deficiency in a patient is provided comprising administering to the patient a therapeutic amount of a triglyceride or other conjugated fatty acid that bypasses or leads to an intermediate that bypasses the deficient enzyme. Amino acid-conjugated fatty acids also are provided as well as compositions comprising the amino acid-conjugated fatty acids.
Claims13
A method of treating a patient having medium chain acyl-CoA dehydrogenase deficiency (MCADD) comprising administering to a patient an effective amount of an active agent triglyceride comprising one to three fatty acid moieties selected from the group consisting of heptanoyl, 2-methylheptanoyl, 2,6-dimethylheptanoyl, 4,8-dimethylnonanoyl, 6-amino-2,4-dimethylheptanoyl, linolenoyl, docosahexaenoyl, and eicosapentaenoyl in any combination, or a pharmaceutically-acceptable salt thereof, effective to treat the MCADD in a patient.
Dependencies are inferred from the claim text.