US 12,213,955 B2 · Compositions and methods for broad-spectrum antiviral therapy

Abstract

AM580 and structurally related compounds have been found to be useful in treating infection by a wide range of RNA and DNA viruses, and also in reducing associated inflammation. This activity is independent of RAR-α signaling, and is not a result of activation of the hosts innate immune response. Broad antiviral activity of AM580 and structurally related compounds is a due to modulation of lipogenesis so as to correct disregulation of this pathway in virus-infected cells, via inhibition of nSREPBP.

Claims14

Dependent claims

A method of treating a viral infection, comprising:

administering to a subject in need thereof, an effective amount of a compound AM580, having the structure:
wherein the viral infection is caused by a virus selected from the group consisting of MERS-CoV, SARS-CoV, Zika virus, Influenza A virus, Human Adenovirus, and Enterovirus.

Dependencies are inferred from the claim text.

Facts

Application

16/757,312Filed 16 Oct 2018 · us provisional application

Priority

18 Oct 2017

Published

US 2020/0338032 A129 Oct 2020

Granted

4 Feb 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/192
Carboxylic acids, e.g. valproic acid: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
Y02A 50/30
In human health protection, e.g. against extreme weather: against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne…

Compositions and methods for broad-spectrum antiviral therapy

Life of this patent

Compositions and methods for broad-spectrum antiviral therapy

Life of this patent

Abstract

Claims14