System, method and computer-accessible medium for catheter-based optical determination of met-myoglobin content for estimating radiofrequency ablated, chronic lesion formation in tissue

A system for determining at least one characteristic of at least one tissue, comprising

• a first electromagnetic radiation source configured to (i) generate at least one first radiation and (ii) provide the at least one first radiation to the at least one tissue so as to partially ablate the at least one tissue;
• a second electromagnetic radiation source configured to (i) generate at least one second radiation, and (ii) provide the at least one second radiation to the at least one tissue;
• a detector arrangement configured to (i) continuously obtain a return radiation from the at least one tissue that is based on the at least one second radiation impacting the at least one tissue and the at least partial ablation caused by the at least one first radiation, (ii) receive diffuse reflectance spectra in a wavelength range of 600 nm-1000 nm based on the illumination procedure, and (iii) provide data associated with at least one further characteristic of the returned radiation;
• and
• a computer processing arrangement configured to continuously determine the at least one characteristic based on the data and the received diffuse reflectance spectra, wherein a separation distance between the second electromagnetic radiation source and the detector arrangement is between 0.8 mm and 1.7 mm.