Systems, methods and devices for removal of thrombus and/or soft plaque with asymmetric mass distribution within working region of impeller

A thrombus disruption and removal system, comprising:

• a drive shaft defining a proximal end and a distal end and an axis of rotation;
• a working region defined near, or at, the distal end of the drive shaft, the working region comprising:
• an impeller hub defining a wall and attached to and/or surrounding the drive shaft;
• a plurality of impeller blades attached to, or integrated with, the impeller hub and extending radially therefrom, wherein the impeller blades are shaped so as to draw tissue during rotation of the impeller hub proximally from a thrombus;
• at least a portion of the drive shaft engaging the impeller hub and extending at least partially through a lumen defined through the impeller hub;
• a prime mover coupled to the proximal end of the drive shaft and, together with the drive shaft, configured to rotate the impeller hub and to translate the working region,
• wherein at least one of the impeller blades comprises a surface area that is greater than the surface area of any one of the remaining impeller blades in the plurality of impeller blades.