Method of applying hemostatic or tissue healing agent to wet surfaces

A method for applying tissue healing agents to a target tissue, comprising:

• inserting an insertion member into a living body to the target tissue to be treated, the insertion member extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, a delivery element housed in the insertion member in a closed configuration in which the delivery element is compressed;
• placing the delivery element distally relative to the insertion member to an open configuration in which the delivery element expands to be substantially planar, the delivery element including a first surface and a second surface opposite the first surface, the first surface including a first tissue healing agent formed in a sheet configuration and disposed thereon by releasing the first tissue healing agent from the delivery element via a first release mechanism which releases the first tissue healing agent from the first surface, applying a second tissue healing agent against a second portion of the target tissue to be treated, the second tissue healing agent being formed in a sheet configuration and disposed on the second surface of the delivery element;
• and
• applying the first tissue healing agent against a first portion of the target tissue to be treated.