Compositions and methods to counteract processes associated with inflammation and senescence and to support cellular energy and/or metabolism

A method of supplementing human nutrition, comprising:

• administering to a human a nutritional supplement that consists of:
• a nutritionally acceptable carrier;
• a plurality of polyphenol-containing plant materials consisting of:
• red color, green color, orange-yellow color, and purple-blue color;
• wherein the red colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an apple extract,
• about 10 wt. % of a pomegranate extract,
• about 1.85 wt. % of a tomato powder, and
• about 2.45 wt. % of a beet root powder,
• wherein the green colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 6.38 wt. % of an olive extract,
• about 7.5 wt. % of a rosemary extract,
• about 7.5 wt. % of a green coffee bean extract, and
• about 2.5 wt. % of a kale powder,
• wherein the orange-yellow colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an onion extract,
• about 10 wt. % of a ginger extract,
• about 2.5 wt. % of a grapefruit extract, and
• about 2.45 wt. % of a carrot powder,
• wherein the purple-blue colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 15.75 wt. % of a grape extract,
• about 2.5 wt. % of a blueberry extract,
• about 2.43 wt. % of a black currant powder, and
• about 2.43 wt. % of an elderberry powder;
• about 3.19 wt. % of maltodextrin;
• about 0.31 wt. % of corn starch;
• about 0.25 wt. % of slica;
• and
• about 0.03 wt. % of sunflower lecithin;
• wherein the nutritionally acceptable carrier is present in an amount to balance the nutritional supplement to 100 wt. %;
• wherein the plant materials and/or polyphenols contained therein, when tested in vitro, reduces
• (a) at least one pro-inflammatory cytokine in human primary monocytes at a dosage of at least 10 μg/mL,
• (b) NFiB signaling in HEK293T cells at a dosage of at least 50 μg/mL, and/or
• (c) at least one pro-inflammatory adipokine in mouse 3T3-L1 cells at a dosage of at least 10 μg/mL.

A method of supplementing human nutrition, comprising:

• administering to a human a nutritional supplement comprising:
• a nutritionally acceptable carrier;
• in combination with
• a plurality of polyphenol-containing plant materials comprises:
• red color, green color, orange-yellow color, and purple-blue color;
• wherein the red colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 10 wt. % of an apple extract,
• about 10 wt. % of a pomegranate extract,
• about 1.85 wt. % of a tomato powder, and
• about 2.45 wt. % of a beet root powder,
• wherein the green colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 6.38 wt. % of an olive extract,
• about 7.5 wt. % of a rosemary extract,
• about 7.5 wt. % of a green coffee bean extract, and
• about 2.5 wt. % of a kale powder,
• wherein the orange-yellow colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 10 wt. % of an onion extract,
• about 10 wt. % of a ginger extract,
• about 2.5 wt. % of a grapefruit extract, and
• about 2.45 wt. % of a carrot powder,
• wherein the purple-blue colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 15.75 wt. % of a grape extract,
• about 2.5 wt. % of a blueberry extract,
• about 2.43 wt. % of a black currant powder, and
• about 2.43 wt. % of an elderberry powder.

A method of supplementing human nutrition, comprising:

• administering to a human a nutritional supplement consisting of:
• a nutritionally acceptable carrier;
• in combination with
• a plurality of polyphenol-containing plant materials comprises:
• red color, green color, orange-yellow color, and purple-blue color;
• wherein the red colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an apple extract,
• about 10 wt. % of a pomegranate extract,
• about 1.85 wt. % of a tomato powder, and
• about 2.45 wt. % of a beet root powder,
• wherein the green colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 6.38 wt. % of an olive extract,
• about 7.5 wt. % of a rosemary extract,
• about 7.5 wt. % of a green coffee bean extract, and
• about 2.5 wt. % of a kale powder,
• wherein the orange-yellow colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an onion extract,
• about 10 wt. % of a ginger extract,
• about 2.5 wt. % of a grapefruit extract, and
• about 2.45 wt. % of a carrot powder,
• wherein the purple-blue colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 15.75 wt. % of a grape extract,
• about 2.5 wt. % of a blueberry extract,
• about 2.43 wt. % of a black currant powder, and
• about 2.43 wt. % of an elderberry powder;
• wherein the nutritionally acceptable carrier is present in an amount to balance the nutritional supplement to 100 wt. %.

A nutritional supplement comprising:

• a nutritionally acceptable carrier;
• in combination with
• a plurality of polyphenol-containing plant materials comprises:
• red color, green color, orange-yellow color, and purple-blue color;
• wherein the red colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 10 wt. % of an apple extract,
• about 10 wt. % of a pomegranate extract,
• about 1.85 wt. % of a tomato powder, and
• about 2.45 wt. % of a beet root powder,
• wherein the green colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 6.38 wt. % of an olive extract,
• about 7.5 wt. % of a rosemary extract,
• about 7.5 wt. % of a green coffee bean extract, and
• about 2.5 wt. % of a kale powder,
• wherein the orange-yellow colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 10 wt. % of an onion extract,
• about 10 wt. % of a ginger extract,
• about 2.5 wt. % of a grapefruit extract, and
• about 2.45 wt. % of a carrot powder,
• wherein the purple-blue colored plant materials, based on a total weight of the nutritional supplement, comprise:
• about 15.75 wt. % of a grape extract,
• about 2.5 wt. % of a blueberry extract,
• about 2.43 wt. % of a black currant powder, and
• about 2.43 wt. % of an elderberry powder.

A nutritional supplement consisting of:

• a nutritionally acceptable carrier;
• in combination with
• a plurality of polyphenol-containing plant materials comprises:
• red color, green color, orange-yellow color, and purple-blue color;
• wherein the red colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an apple extract,
• about 10 wt. % of a pomegranate extract,
• about 1.85 wt. % of a tomato powder, and
• about 2.45 wt. % of a beet root powder,
• wherein the green colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 6.38 wt. % of an olive extract,
• about 7.5 wt. % of a rosemary extract,
• about 7.5 wt. % of a green coffee bean extract, and
• about 2.5 wt. % of a kale powder,
• wherein the orange-yellow colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 10 wt. % of an onion extract,
• about 10 wt. % of a ginger extract,
• about 2.5 wt. % of a grapefruit extract, and
• about 2.45 wt. % of a carrot powder,
• wherein the purple-blue colored plant materials, based on a total weight of the nutritional supplement, consist of:
• about 15.75 wt. % of a grape extract,
• about 2.5 wt. % of a blueberry extract,
• about 2.43 wt. % of a black currant powder, and
• about 2.43 wt. % of an elderberry powder;
• wherein the nutritionally acceptable carrier is present in an amount to balance the nutritional supplement to 100 wt. %.