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US 12,191,023 B1Granted
Systems and methods for patient targeted therapy development
AssigneeFlagship Pioneering Innovations VI, LLC
InventorsDouglas Gowers Cole, Aaron Garth Day-Williams
Life of this patent
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Abstract
Described herein are platforms for use in targeted therapy development for an individual or group of individuals. Targeted therapy development as described herein comprises developing a therapeutic or therapeutic modality that is specific to or customized to an individual or group of individuals.
Claims20
A process for targeting a therapy to a subgroup of individuals having a health-related condition, abnormality, or disease, the process comprising:
- determining respective characterization parameters for individuals based at least in part on data relating to the individuals as extracted from computer storage, wherein the characterization parameters include a physical parameter and a behavioral parameter;
- determining genetic information for the individuals based on respective biological samples obtained or derived from the individuals;
- generating first data representing a first grouping of the individuals, wherein the individuals in the first grouping have the health-related condition, abnormality, or disease, and wherein the first grouping is based at least in part on the respective characterization parameters and the respective genetic information, such that the first grouping includes individuals who share one or more of the characterization parameters and one or more of the genetic information;
- applying a stimulation based on the therapy to respective cell cultures grown from cells taken from respective biological samples obtained or derived from selected individuals in the first grouping;
- measuring any respective modulation in the respective cell cultures caused by the stimulation to a characterization parameter or genetic information from among the one or more of the characterization parameters and the one or more of the genetic information defining the first grouping, thereby generating respective screening results for the biological samples;
- generating data representing a second grouping of the individuals, such that the second grouping includes individuals from the first grouping who further share one or more of an additional characterization parameter or genetic information correlated with the respective screening results indicating the individuals in the second grouping are predicted to respond to the therapy;
- and
- administering the therapy to an individual who shares the one or more of the characterization parameters and the one or more of the genetic information with the individuals in the first grouping and who further shares the one or more of the additional characterization parameter or genetic information with the individuals in the second grouping.
5 more elements
A process for targeting a therapy to a subgroup of individuals having a health-related condition, abnormality, or disease, the process comprising:
- determining respective characterization parameters for individuals based at least in part on data relating to the individuals as extracted from computer storage, wherein the characterization parameters include a physical parameter and a behavioral parameter;
- determining genetic information for the individuals based on respective biological samples obtained or derived from the individuals;
- generating first data representing a first grouping of the individuals, wherein the individuals in the first grouping have the health-related condition, abnormality, or disease, and wherein the first grouping is based at least in part on the respective characterization parameters and the respective genetic information, such that the first grouping includes individuals who share one or more of the characterization parameters and one or more of the genetic information;
- applying a stimulation based on the therapy to respective cell cultures grown from cells taken from respective biological samples obtained or derived from selected individuals in the first grouping;
- measuring any respective modulation in the respective cell cultures caused by the stimulation to a characterization parameter or genetic information from among the one or more of the characterization parameters and the one or more of the genetic information defining the first grouping, thereby generating respective screening results for the biological samples;
- generating data representing a second grouping of the individuals, such that the second grouping includes individuals from the first grouping who further share one or more of an additional characterization parameter or genetic information correlated with the respective screening results indicating the individuals in the second grouping are predicted to respond to the therapy;
- outputting the data representing the second grouping as indicative of the subgroup of the individuals having the health-related condition, abnormality, or disease who are predicted to respond to the therapy;
- and
- administering the therapy to an individual who shares the one or more of the characterization parameters and the one or more of the genetic information with the individuals in the first grouping and who further shares the one or more of the additional characterization parameter or genetic information with the individuals in the second grouping.
6 more elements
Dependencies are inferred from the claim text.