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US 12,187,808 B2Granted
GD2-based chimeric antigen receptor and application thereof
AssigneeBeijing Meikang Geno-Immune Biotechnology Co., Ltd.
InventorYu Chen Liu
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Abstract
The present application relates to a GD2-based chimeric antigen receptor comprising an antigen-binding domain, a transmembrane domain, a costimulatory signaling domain, a CD3ζ signaling domain, and a self-destructive domain in tandem arrangement; wherein the antigen-binding domain binds to a tumor surface antigen, wherein the tumor surface antigen is GD2, and the antigen-binding domain is a single-chain antibody against the tumor surface antigen GD2, wherein the self-destructive domain is a caspase 9 domain.
Claims10
A chimeric antigen receptor, wherein
- the chimeric antigen receptor comprises a Secretory signal peptide, GD2 antigen-binding domain, CD8α and/or CD28 transmembrane domain, CD28 signaling domain, 4-1BB signaling domain, CD3ζ signaling domain, 2A sequence, and caspase 9 domain in tandem arrangement;
- the chimeric antigen receptor is Secretory-GD2-CD28-4-1BB-CD3ζ-2A-FBKP.Casp9;
- and
- the chimeric antigen receptor Secretory-GD2-CD28-4-1BB-CD3ζ-2A-FBKP.Casp9 comprises the amino acid sequence as shown in SEQ ID NOs:
- 13-14.
2 more elements
Dependencies are inferred from the claim text.