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US 12,183,434 B2Granted
Diagnostic and therapeutic methods for cancer
AssigneeGenentech, Inc.
InventorsZia Khan, Matthew Lawrence Albert, G Scott Chandler
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Abstract
Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.
Claims21
A method of treating an individual having a metastatic urothelial carcinoma (mUC), the method comprising:
- (a) determining a determining a polygenic risk score (PRS) for one or more of vitiligo, psoriasis, and atopic dermatitis from a sample from the individual, wherein:
- (i) the PRS for vitiligo from the sample is above a vitiligo reference PRS, wherein the vitiligo reference PRS is the median PRS for vitiligo in a reference population;
- (ii) the PRS for psoriasis from the sample is above a psoriasis reference PRS, wherein the psoriasis reference PRS is the median PRS for psoriasis in a reference population;
- or
- (iii) the PRS for atopic dermatitis from the sample is below an atopic dermatitis reference PRS, wherein the atopic dermatitis reference PRS is the median PRS for atopic dermatitis in a reference population,
- thereby identifying the individual as one who may benefit from a treatment comprising atezolizumab;
- and
- (b) administering an effective amount of atezolizumab to the individual.
5 more elements
Dependencies are inferred from the claim text.