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US 12,180,484 B2Granted
Chimeric antigen receptors targeting B-cell maturation antigen
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorJames N. Kochenderfer
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Abstract
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
Claims20
A human T cell comprising a nucleic acid that encodes a chimeric antigen receptor (CAR) comprising:
- (a) an antigen recognition moiety that binds human B-Cell Maturation Antigen (BCMA);
- (b) a CD8α hinge domain;
- (c) a CD8α transmembrane domain;
- (d) a 4-1BB intracellular T cell signaling domain;
- and
- (e) a CD3ζ intracellular T cell signaling domain.
3 more elements
Dependencies are inferred from the claim text.