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US 12,180,474 B2Granted
Methods of treating porphyria
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsSatdarshan Monga, Kari Nejak-Bowen
Life of this patent
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Abstract
A method of treating porphyria in a patient is provided comprising knocking down or reducing expression or activity of β-catenin in the patient. e.g., in the liver of a patient, to an extent effective to treat porphyria in a patient.
Claims19
A method of treating porphyria in a patient in need thereof, comprising:
- decreasing porphyrin production and/or accumulation in the patient by administering to the patient an amount of a therapeutic agent effective to decrease porphyrin production and/or accumulation in the patient, wherein the therapeutic agent is selected from the group consisting of Wnt-C59, PRI724, ICG001, an isomer, stereoisomer, or enantiomer of ICG001, and combinations thereof.
A method of decreasing porphyrin production in a patient, comprising:
- administering to the patient an amount of a therapeutic agent effective to decrease porphyrin production in the patient, wherein the therapeutic agent is selected from the group consisting of Wnt-C59, PRI724, ICG001 an isomer, stereoisomer, or enantiomer of ICG001, and combinations thereof.
A method of decreasing porphyrin accumulation in a patient, comprising:
- administering to the patient an amount of a therapeutic agent effective to decrease porphyrin accumulation in the patient, wherein the therapeutic agent is selected from the group consisting of Wnt-C59, PRI724, ICG001 an isomer, stereoisomer, or enantiomer of ICG001, and combinations thereof.
Dependencies are inferred from the claim text.