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US 12,180,465 B2Granted
Transglutaminase nanoflowers
AssigneeIndian Institute of Technology Delhi
InventorsSunil Kumar Khare, Syeda Warisul Fatima
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Abstract
The present invention relates to novel immobilized nanoflowers made of Transglutaminase (TGase), a method for their synthesis and applications thereof. The Transglutaminase nanoflowers of the present invention are catalytically more active without mass transfer limitation, stable and reusable, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein Transglutaminase functions both as a cross-linking enzyme and as a seeding template.
Claims15
Immobilized Transglutaminase nanoflowers, comprising:
- Transglutaminase and an inorganic metal, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein
- the transglutaminase is a template for the formation of the flowers that are immobilize to the structure of the transglutaminase, and
- wherein said nanoflowers can tolerate cold temperature and possess higher durability in terms of organic solvents, temperature, pH, storage and operational stability, having higher catalytic efficiency of 6.92 fold as compared to free Transglutaminase without any mass transfer limitation.
Dependencies are inferred from the claim text.