Packed-bed bioreactor systems and methods of using the same
AssigneeCorning Incorporated
InventorsAnn MeeJin Ferrie, Vasiliy Nikolaevich Goral
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Abstract
A bioreactor system is provided that includes a cell culture vessel having a first end, a second end, and at least one reservoir between the first and second ends; and a cell culture matrix disposed in the at least one reservoir. The cell culture matrix has a structurally defined substrate with a surface for adhering cells thereto. The bioreactor system flows material through the at least one reservoir and through the cell culture matrix in a flow direction from the first end to the second end, and the cell culture matrix exhibits isotropic fluid flow permeability therethrough.
Claims20
A bioreactor system comprising:
- a cell culture vessel comprising a first end, a second end, and at least one reservoir between the first and second ends;
- and
- a cell culture matrix disposed in the at least one reservoir, the cell culture matrix comprising a structurally defined substrate comprising a surface configured for adhering cells thereto,
- wherein the bioreactor system is configured to flow material through the at least one reservoir and through the cell culture matrix in a flow direction from the first end to the second end, and
- wherein the cell culture matrix exhibits isotropic fluid flow permeability therethrough.
Dependencies are inferred from the claim text.