Interleukin-13 binding cyclic oligopeptides and methods of use thereof
AssigneeB.A.I. Laboratories, LLC
InventorsXuefei Bai, Sheng Lin, Le Li
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Abstract
The present disclosure relates to cyclic oligopeptides that bind to interleukin-13 (IL-13) which are useful therapeutically in methods of treating or preventing IL-13-associated skin disorders or conditions. The present disclosure also provides methods to treat or prevent IL-13-associated skin disorders or conditions with the IL-13-binding cyclic oligopeptides. The present disclosure further provides methods to produce the IL-13-binding cyclic oligopeptides.
Claims10
A cyclic oligopeptide, wherein the cyclic oligopeptide is selected from the group consisting of any one of Compounds 1-11
- and
- or a pharmaceutically acceptable salt of any of the foregoing.
A pharmaceutical composition comprising a cyclic oligopeptide and a pharmaceutically acceptable carrier, wherein the cyclic oligopeptide is selected from the group consisting of any one of Compounds 1-11
- or a pharmaceutically acceptable salt of any of the foregoing.
A method of treating atopic dermatitis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a cyclic oligopeptide or a pharmaceutical composition comprising the cyclic oligopeptide and a pharmaceutically acceptable carrier, wherein the cyclic oligopeptide is selected from the group consisting of any one of Compounds 1-11
- or a pharmaceutically acceptable salt of any of the foregoing.
Dependencies are inferred from the claim text.