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US 12,180,302 B2Granted
Heterodimeric antibodies that bind fibroblast activation protein
AssigneeXencor, Inc.
InventorsJohn Desjarlais, Alex Nisthal, Seung Chu
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel antigen binding domains and heterodimeric antibodies that bind Fibroblast Activation Protein (FAP).
Claims10
A composition comprising a fibroblast activation protein (FAP) binding domain, the FAP binding domain comprising:
- a) a variable heavy domain comprising a vhCDR1, vhCDR2, and vhCDR3;
- and
- b) a variable light domain comprising a vlCDR1, vlCDR2, and vlCDR3;
- wherein vhCDR1-3 and vlCDR1-3 are selected from the following:
- i) a vhCDR1 having the amino acid sequence of SEQ ID NO:
- 158, a vhCDR2 having the amino acid sequence of SEQ ID NO:
- 159, a vhCDR3 having the amino acid sequence of SEQ ID NO:
- 160, a vlCDR1 having the amino acid sequence of SEQ ID NO:
- 162, a vlCDR2 having the amino acid sequence of SEQ ID NO:
- 163, and a vlCDR3 having the amino acid sequence of SEQ ID NO:
- 164;
- ii) a vhCDR1 having the amino acid sequence of SEQ ID NO:
- 166, a vhCDR2 having the amino acid sequence of SEQ ID NO:
- 167, a vhCDR3 having the amino acid sequence of SEQ ID NO:
- 168, a vlCDR1 having the amino acid sequence of SEQ ID NO:
- 170, a vlCDR2 having the amino acid sequence of SEQ ID NO:
- 171, and a vlCDR3 having the amino acid sequence of SEQ ID NO:
- 172;
- iii) a vhCDR1 having the amino acid sequence of SEQ ID NO:
- 182, a vhCDR2 having the amino acid sequence of SEQ ID NO:
- 183, a vhCDR3 having the amino acid sequence of SEQ ID NO:
- 184, a vlCDR1 having the amino acid sequence of SEQ ID NO:
- 186, a vlCDR2 having the amino acid sequence of SEQ ID NO:
- 187, and a vlCDR3 having the amino acid sequence of SEQ ID NO:
- 188;
- and
- iv) a vhCDR1 having the amino acid sequence of SEQ ID NO:
- 190, a vhCDR2 having the amino acid sequence of SEQ ID NO:
- 191, a vhCDR3 having the amino acid sequence of SEQ ID NO:
- 192, a vlCDR1 having the amino acid sequence of SEQ ID NO:
- 194, a vlCDR2 having the amino acid sequence of SEQ ID NO:
- 195, and a vlCDR3 having the amino acid sequence of SEQ ID NO:
- 196.
30 more elements
A composition comprising a fibroblast activation protein (FAP) binding domain, wherein the FAP binding domain comprises a variable heavy domain and a variable light domain selected from the following:
- i) a variable heavy domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 157, and a variable light domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 161;
- ii) a variable heavy domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 165, and a variable light domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 169;
- iii) a variable heavy domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 181, and a variable light domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 185;
- and
- iv) a variable heavy domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 189, and a variable light domain having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 193.
10 more elements
Dependencies are inferred from the claim text.