Heavy chain antibodies binding to PSMA
AssigneeTeneoBio, Inc.
InventorsWim van Schooten, Starlynn Clarke, Kevin Dang, Ben Buelow
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Abstract
Anti-PSMA heavy chain antibodies are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat disorders that are characterized by the expression of PSMA.
Claims28
An antigen-binding region of an anti-PSMA heavy chain antibody, comprising a CDR1 sequence of SEQ ID NO:
- 2, a CDR2 sequence of SEQ ID NO:
- 11, and a CDR3 sequence of SEQ ID NO:
- 18.
An antibody comprising an antigen-binding region of an anti-PSMA heavy chain antibody, wherein the antigen-binding region comprises a CDR1 sequence of SEQ ID NO:
- 2, a CDR2 sequence of SEQ ID NO:
- 11, and a CDR3 sequence of SEQ ID NO:
- 18.
A three-chain antibody-like molecule that binds to a CD3 protein and a PSMA protein, comprising:
- a first polypeptide comprising the sequence of SEQ ID NO:
- 86;
- a second polypeptide comprising the sequence of SEQ ID NO:
- 87;
- and
- a third polypeptide comprising the sequence of SEQ ID NO:
- 88, 89, 90, 91, 92, or 93.
A three-chain antibody-like molecule comprising:
- (a) a PSMA-binding heavy chain variable region comprising:
- a CDR1 sequence of the formula G G S I S S X1 X2 Y X3 (SEQ ID NO:
- 67), wherein X1 is S or N;
- X2 is S or N;
- and X3 is Y or F;
- and
- a CDR2 sequence of the formula X4 X5 X6 S G X7 T (SEQ ID NO:
- 68), wherein X4 is I or V;
- X5 is D or Y;
- X6 is Y or D;
- and X7 is Y or S;
- and
- a CDR3 sequence of SEQ ID NO:
- 18;
- and
- (b) a CD3-binding heavy chain variable region that is paired with a light chain variable region, wherein:
- the CD3-binding heavy chain variable region comprises a CDR1 sequence of SEQ ID NO:
- 59, a CDR2 sequence of SEQ ID NO:
- 60, and a CDR3 sequence of SEQ ID NO:
- 61;
- and
- the light chain variable region comprises a CDR1 sequence of SEQ ID NO:
- 62, a CDR2 sequence of GAS, and a CDR3 sequence of SEQ ID NO:
- 64.
Dependencies are inferred from the claim text.