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US 12,180,288 B2Granted
Antibodies to canine interleukin-4 receptor alpha
AssigneeIntervet Inc.
InventorsMohamad Morsey, Yuanzheng Zhang
Life of this patent
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Abstract
The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor α. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.
Claims17
An antibody or antigen binding fragment thereof that binds to canine interleukin-4 receptor α (IL-4Rα), wherein the antibody or antigen binding fragment thereof comprises:
- (i) a light chain variable region (VL) comprising a VL complementarity determining region (CDR) 1, a VL CDR2, and a VL CDR3 having an amino acid sequence of a VL CDR1, a VL CDR2, and a VL CDR3, respectively, of a VL having the amino acid sequence of SEQ ID NO:120;
- and
- (ii) a VH comprising a VH CDR1, a VH CDR2, and a VH CDR3 having an amino acid sequence of a VH CDR1, a VH CDR2, and a VH CDR3, respectively, of a VH having the amino acid sequence of SEQ ID NO:118.
Dependencies are inferred from the claim text.