Antibodies and antibody-drug conjugates targeting claudin 6
AssigneeLaNova Medicines Limited Company
InventorsRunsheng Li, Wentao Huang, Ying Qin Zang, Zhifang Liu
Life of this patent
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Abstract
Provided are antibodies and fragments thereof having binding specificity to the claudin 6 (CLDN6) protein as well as their derivatives and uses.
Claims26
An antibody or antigen-binding fragment thereof that has binding specificity to the human Claudin 6 (CLDN6) protein, wherein the antibody or the fragment thereof comprises a heavy chain variable region (VH) comprising heavy chain complementarity determining regions (CDR) VH CDR1, VH CDR2, and VH CDR3, and a light chain variable region (VL) comprising VL CDR1, VL CDR2, and VL CDR3, and wherein the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3, respectively, comprise:
- (a) the amino acid sequences of SEQ ID NO:19, 73, 21, 22, 23 and 24;
- (b) the amino acid sequences of SEQ ID NO:19-24;
- (c) the amino acid sequences of SEQ ID NO:25-30;
- (d) the amino acid sequences of SEQ ID NO:31-36;
- (e) the amino acid sequences of SEQ ID NO:37-42;
- (f) the amino acid sequences of SEQ ID NO:43-48;
- (g) the amino acid sequences of SEQ ID NO:49-54;
- (h) the amino acid sequences of SEQ ID NO:55-60;
- (i) the amino acid sequences of SEQ ID NO:61-66;
- or
- (j) the amino acid sequences of SEQ ID NO:67-72.
Dependencies are inferred from the claim text.