Antigen binding molecule formats

A bispecific antigen-binding molecule comprising:

• (a) a first polypeptide chain comprising in an N-to-C terminal orientation:
• (i) a first Fc domain;
• and
• (ii) a first Fab domain that binds to a cytokine and comprises a first heavy chain variable region (VH) domain associated with a first light chain variable region (VL) domain;
• and
• (b) a second polypeptide chain comprising in an N-to-C terminal orientation:
• (i) a second Fc domain associated with the first Fc domain to form an Fc heterodimer;
• and
• (ii) a second Fab domain that is non-identical to the first Fab domain, binds to the cytokine, and comprises a second VH domain associated with a second VL domain;
• (c) a third polypeptide chain associated with the first polypeptide, the third polypeptide comprising in an N-to-C terminal orientation:
• (i) the first VL domain;
• and
• (ii) a first constant domain of the light chain (CL) domain;
• and
• (d) a fourth polypeptide chain associated with the second polypeptide, the fourth polypeptide comprising in an N-to-C terminal orientation:
• (i) the second VL domain;
• and
• (ii) a second CL domain,
• wherein the first Fab domain and the second Fab domain are the only antigen-binding domains in the antigen-binding molecule.