Anti-ANGPTL 3/8 complex antibodies and methods of using the same

An antibody produced by:

• (i) cultivating a mammalian cell comprising a cDNA molecule, wherein the cDNA molecule encodes a polypeptide comprising the amino acid sequence of one of SEQ ID NOs:5, 21, 22, 23, 24, and 25, and the cDNA molecule encodes a heavy chain for the antibody comprising a HCVR comprising the amino acid sequence of SEQ ID NO:
• 10, and the mammalian cell is cultivated under such conditions that the encoded polypeptides are expressed;
• and (ii) recovering the antibody.

An antibody produced by:

• (i) cultivating a mammalian cell comprising at least two cDNA molecules, wherein a first cDNA molecule encodes a light chain for the antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:5, 21, 22, 23, 24 and 25 and a second cDNA molecule encodes a heavy chain for the antibody comprising a HCVR comprising the amino acid sequence of SEQ ID NO:
• 10, and the mammalian cell is cultivated under such conditions that the antibody is expressed;
• and (ii) recovering the antibody.

A mammalian cell comprising a DNA molecule, wherein the DNA molecule comprises a polynucleotide sequence encoding a polypeptide comprising the amino acid sequence of one of SEQ ID NOs:5, 21, 22, 23, 24, and 25, and the DNA molecule comprises a polynucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:

• 10, wherein the cell is capable of expressing the encoded polypeptides.

A mammalian cell comprising a first DNA molecule and a second DNA molecule, wherein the first DNA molecule comprises a polynucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:5, 21, 22, 23, 24 or 25, and wherein the second DNA molecule comprises a polynucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:

• 10, wherein the cell is capable of expressing the polypeptides.