GRP78-binding antibodies and uses thereof in detecting or neutralizing GRP78
AssigneeRutgers, The State University of New Jersey
InventorsRenata Pasqualini, Wadih Arap, Fernanda Iamassaki Staquicini, Fortunato Ferrara, Sara D'Angelo, Andrew R. M. Bradbury
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Abstract
Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
Claims26
An isolated monoclonal antibody, wherein the antibody specifically binds to GRP78 (78 kDa glucose-regulated protein) and comprises:
- a heavy chain variable region (VH) comprising a VH CDR1 having the amino acid sequence set forth in SEQ ID NO:
- 55, a VH CDR2 having the amino acid sequence set forth in SEQ ID NO:
- 56, and a VH CDR3 having the amino acid sequence set forth in SEQ ID NO:
- 57;
- and
- a light chain variable region (VL) comprising a VL CDR1 having the amino acid sequence set forth in SEQ ID NO:
- 58, a VL CDR2 having the amino acid sequence set forth in SEQ ID NO:
- 59, and a VL CDR3 having the amino acid sequence set forth in SEQ ID NO:
- 60.
Dependencies are inferred from the claim text.