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US 12,180,267 B2Granted
Methods and composition for neutralization of influenza
AssigneeThe University of Chicago
InventorsPatrick Wilson, Yaoqing Chen, Haley L. Dugan
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Abstract
Provided herein are anti-neuraminidase agents useful for neutralization of influenza virus infection, and methods of use and manufacture thereof. In particular, compositions comprising anti-neuraminidase agents (e.g., antibodies) that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.
Claims10
An antibody or antibody fragment comprising a heavy chain variable region comprising a CDR1 of SEQ ID NO:
- 20, a CDR2 of SEQ ID NO:
- 22 and CDR3 of SEQ ID NO:
- 24, and a light chain variable region comprising a CDR1 of SEQ ID NO:
- 28, a CDR2 of SEQ ID NO:
- 30 and CDR3 of SEQ ID NO:
- 32 wherein the antibody or antibody fragment is capable of binding to influenza neuraminidase (NA) protein.
3 more elements
Dependencies are inferred from the claim text.