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AssigneeAlcamena Stem Cell Therapeutics, LLC
InventorsEdmund Nesti, Alexander Pisarchik
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The invention relates to compounds, compositions, and methods for derepressing RE1 silencing transcription factor (REST) target genes are provided. In particular, a peptide having the sequence TEDLEPPEPPLPKEN (SEQ. ID NO: 1) and EDLEPPEPPLPK (SEQ. ID NO: 15), or the reversed sequences made of D-amino acids (retro inverted, RI) nekplppeppeldet (SEQ ID NO: 16) and kplppeppelde (SEQ ID NO: 17), are disclosed for inhibiting REST activity. The peptides are useful to treat, prevent, or ameliorate conditions such as traumatic brain injury, epilepsy, dementia, Huntington's Disease (HD), chronic pain, brain cancer (including glioblastoma multiforme), pancreatic cancer; diabetes, and peripheral nerve injury.
An isolate peptide comprising an amino acid sequence, wherein the amino acid sequence is selected from the group consisting of SEQ ID NOS:
An isolate peptide comprising an amino acid sequence, wherein the amino acid sequence is a cyclized fusion peptide selected from the group consisting of SEQ ID NOS:
An isolate peptide comprising an amino acid sequence, wherein the amino acid sequence is a fusion peptide selected from the group consisting of SEQ ID NOS:
Dependencies are inferred from the claim text.