Back to results
US 12,180,251 B2Granted
Nucleic acids encoding peptides that block binding of a2d-1 to glutamate receptors for treating diseases and disorders
AssigneeBoard of Regents, The University of Texas System
InventorHui-Lin Pan
Life of this patent
Estimating the term…
Abstract
The present disclosure provides α2δ-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an α2δ-1 C-terminal domain peptide which blocks binding of α2δ-1 to the glutamate receptors NMDAR and AMPAR.
Claims19
An isolated nucleic acid encoding a peptide, the peptide comprising the amino acid sequence SEQ ID NO:1 and a cell-penetrating peptide, wherein said peptide blocks binding of α2δ-1 to a glutamate receptor.
Dependencies are inferred from the claim text.