Back to results
US 12,180,248 B2Granted
Compositions and methods for treating CNS disorders
AssigneeSage Therapeutics, Inc.
InventorsGabriel Martinez Botella, Francesco G. Salituro, Albert Jean Robichaud, Boyd L. Harrison
Life of this patent
Estimating the term…
Abstract
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R1, R2a, R2b, R3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
Claims2
A compound having the structure
- or a pharmaceutically acceptable salt thereof.
A process for preparing a compound of Formula (A17) or Formula (A18):
- comprising treating a compound of Formula (A16)
- with HBr and Br2, wherein the process is performed in MeOH at room temperature.
Dependencies are inferred from the claim text.